Treatment of Experimental Bacterial Keratitis With Topical Trovafloxacin
نویسندگان
چکیده
منابع مشابه
Treatment of experimental bacterial keratitis with topical trovafloxacin.
OBJECTIVE To investigate the therapeutic role of trovafloxacin mesylate, a newer-generation fluoroquinolone with an expanded spectrum of activity, in the treatment of experimental bacterial keratitis. METHODS Susceptibility studies were performed on various strains of ocular isolates to determine the minimum inhibitory concentration (MIC) of trovafloxacin compared with ciprofloxacin and oflox...
متن کاملUse of adjunctive topical corticosteroids in bacterial keratitis.
PURPOSE OF REVIEW Topical corticosteroid use in the setting of infectious keratitis has been a controversial issue. The aim of this review is to provide an update on the evidence for use of topical corticosteroids in addition to antibiotics in bacterial keratitis. RECENT FINDINGS Judicious use of steroids is postulated to limit the inflammatory component of bacterial keratitis, but can theore...
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Bacterial keratitis can cause significant morbidity from ulceration of the cornea and the resultant scarring. The use of steroids to decrease these complications is controversial with arguments for and against their use. The SCUT (Steroids for Corneal Ulcers Trial) was initiated in 2006 to definitively determine whether steroids in bacterial keratitis were beneficial or harmful. While the SCUT ...
متن کاملEarly addition of topical corticosteroids in the treatment of bacterial keratitis.
IMPORTANCE Scarring from bacterial keratitis remains a leading cause of visual loss. OBJECTIVE To determine whether topical corticosteroids are beneficial as an adjunctive therapy for bacterial keratitis if given early in the course of infection. DESIGN, SETTING, AND PARTICIPANTS The Steroids for Corneal Ulcers Trial (SCUT) was a randomized, double-masked, placebo-controlled trial that over...
متن کاملTopical fluconazole for experimental candida keratitis in rabbits.
Using a reproducible model of Candida albicans keratitis in rabbits we studied the effect of topical fluconazole, a new triazole. Candida albicans DSM 70010 (2.5 X 10(5) cells) was injected into the corneal stroma of both eyes of 21 rabbits. All eyes developed a corneal ulcer. Forty-eight hours after inoculation the animals were divided into three groups: (1) 14 eyes, received fluconazole (2 mg...
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ژورنال
عنوان ژورنال: Archives of Ophthalmology
سال: 2004
ISSN: 0003-9950
DOI: 10.1001/archopht.122.1.65